4-Hydroxycyclohexanone ethylene acetal, identified by CAS 22428-87-1, is a protected cyclohexanone derivative used primarily as a pharmaceutical and fine-chemical intermediate. The ethylene acetal protects the ketone functionality, while the hydroxyl group provides a separate site for downstream transformation. When I evaluate this material for a B2B purchase, I focus first on identity confirmation, assay and impurity requirements, documentation, packaging, and supply continuity rather than on price alone.
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This guide explains what buyers should verify before requesting a quotation or approving a supplier. The compound is commonly represented by the molecular formula C8H14O3, with an approximate molecular weight of 158.20 g/mol; buyers should confirm these details against the supplier’s current technical documentation. Maison Chemical supports commercial inquiries for this pharmaceutical intermediate by aligning product information, quality expectations, packaging, and delivery requirements before order confirmation.
I have written this guide for procurement teams, pharmaceutical process chemists, medicinal chemistry groups, contract development and manufacturing organizations, and distributors sourcing CAS 22428-87-1. It is also useful for buyers who already know the chemical name but need to distinguish a technically suitable material from a quotation that lacks sufficient evidence. The guidance applies to laboratory evaluation, process development, and commercial sourcing, although acceptance criteria may differ between these stages.
Early-stage research may tolerate a broader specification while a regulated or scale-up project usually requires stronger control of impurities, analytical methods, change notification, and batch traceability. For that reason, a supplier should not be selected solely because a product page lists the correct CAS number. The practical question is whether the supplier can provide the information and consistency required for your intended use.
4-Hydroxycyclohexanone ethylene acetal contains a cyclohexane framework with a protected ketone and a hydroxyl substituent. In synthetic planning, acetal protection can help differentiate the original ketone from other reactive groups during selected chemical transformations. The hydroxyl group may then be used in functionalization steps such as derivatization or substitution, depending on the route and reaction conditions.
The word “ethylene acetal” is important because it describes the protecting-group form of the ketone rather than the unprotected ketone itself. A buyer should therefore check the product name, CAS number, structural representation, molecular formula, and molecular weight together. If any of these identifiers conflict, I recommend placing the order on hold until the supplier explains the discrepancy in writing.
At a minimum, I recommend requesting a current specification sheet, SDS, and batch-specific Certificate of Analysis. The CoA should identify the tested batch, analytical methods or method references, release date, and reported results. For technical qualification, a representative HPLC, GC, NMR, or other relevant spectrum may also be useful, but the appropriate package depends on the buyer’s internal quality system.
Assay is usually an important starting point, but it should not be the only acceptance criterion. Buyers should also discuss related substances, water content, residual solvents, inorganic residues, and physical appearance where these attributes affect the next synthetic step. If a project has a defined internal standard, provide it to the supplier before quotation so that the offer is based on the actual requirement.
For example, a buyer may request an assay target of not less than 98.0% as an initial screening specification, but this is an example of a procurement requirement and not a claim about every available batch. The final value should be agreed through the product specification and verified by the CoA. I also advise buyers to ask whether results are reported on an as-is basis or corrected for water, solvent, or another factor.
Analytical method compatibility can affect purchasing decisions. Ask how the supplier measures assay and impurities, whether the method is internally validated or routinely used for release, and whether chromatographic conditions can be shared for method transfer. Packaging should be selected according to quantity, handling requirements, moisture sensitivity, and the time the material may remain in storage.
Do not assume that a small research package and a production package have identical controls. A buyer moving from 100 g laboratory evaluation to a 25 kg development requirement should request confirmation of packaging configuration, inner-container material, labeling, batch numbering, and shipping conditions. These details reduce the risk of receiving material that is chemically correct but operationally unsuitable.
The principal value of this intermediate is its combination of a protected ketone and a hydroxyl group. This functionality can support route design in pharmaceutical intermediate synthesis, building-block preparation, and custom organic synthesis. However, the exact suitability depends on the reaction sequence, catalyst system, solvent, temperature, and impurity sensitivity of the buyer’s process.
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I recommend supplying the vendor with a short application profile rather than only a product name. Include the planned use, approximate annual demand, desired assay, prohibited impurities, packaging preference, and whether the material is for research, process development, or commercial manufacture. This information helps a supplier propose a more relevant grade and prevents unnecessary disagreement after the quotation stage.
Compare the CAS number, chemical name, formula, molecular weight, and structural description across the quotation, SDS, specification, and CoA. If the supplier uses a synonym, ask for confirmation that it refers to the same substance. I would also check whether the offered material is a single defined compound or a mixture, solution, or product supplied with a carrier.
Write down the minimum assay, maximum impurity levels, water limit, residual solvent expectations, appearance, and packaging before collecting offers. A clear specification allows procurement teams to compare equivalent materials instead of comparing incomplete price statements. It also provides a reference for future batch review and supplier performance monitoring.
Ask for the available batch size, minimum order quantity, packaging options, production or dispatch lead time, quotation validity, and shipping terms. Lead time should be confirmed for the requested quantity rather than assumed from a laboratory stock statement. If the material is needed for a scheduled campaign, I recommend adding a buffer of at least 2 weeks to the internal purchasing plan for document review, import coordination, and release activities.
A suitable supplier should be able to explain how it manages batch records, specification changes, packaging changes, and repeat orders. Buyers should ask how quickly technical questions are answered and who will coordinate quality, logistics, and commercial issues. These service factors are particularly important when the compound is part of a multi-step process where a delayed intermediate can affect an entire production schedule.
One common mistake is treating the CAS number as complete proof of quality. The CAS number helps identify the substance, but it does not by itself confirm assay, impurity levels, manufacturing route, packaging, or batch availability. Another mistake is accepting a generic “high purity” statement without a numerical specification and batch-specific evidence.
Buyers also sometimes compare a low unit price without including freight, import charges, testing, repackaging, or the cost of a failed batch. A further risk is asking for a quotation without stating the required quantity and delivery destination, which can produce an unrealistic commercial estimate. I recommend resolving these points at the inquiry stage rather than after purchase order issuance.
As a chemicals manufacturer, supplier, and exporter, Maison Chemical approaches CAS 22428-87-1 inquiries by first clarifying the buyer’s technical and commercial requirements. We can discuss the requested specification, intended application, quantity, packaging, destination, and documentation needed for internal approval. This approach helps separate a simple sample request from a development or recurring supply program.
For qualified inquiries, I recommend preparing the following information before contacting Maison Chemical: required quantity, target assay, acceptable impurity limits, preferred package size, delivery country, and expected purchasing frequency. If your organization has a supplier questionnaire or quality agreement format, sharing the relevant requirements early can make the evaluation more efficient. Final availability, specification, price, MOQ, and lead time should always be confirmed in a formal quotation.
| Evaluation area | Questions to ask |
|---|---|
| Identity | Do the name, CAS 22428-87-1, formula, molecular weight, and structure agree? |
| Quality | Are assay, impurities, water, residual solvents, and appearance clearly specified? |
| Documentation | Can the supplier provide SDS, specification, CoA, and relevant analytical information? |
| Supply | Are batch size, MOQ, packaging, lead time, and repeat-order planning explained? |
| Service | Can technical, quality, export, and logistics questions be handled by a clear contact team? |
For most B2B buyers, the right way to purchase 4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 is to verify identity first, define a measurable specification second, and evaluate supply reliability third. The chemical name and CAS number establish the starting point, but the CoA, analytical package, packaging details, and commercial terms determine whether the material is suitable for your project. I would not approve a supplier until these points are consistent and documented.
Your next step is to prepare a concise inquiry containing the required quantity, target quality, application stage, packaging preference, destination, and documentation expectations. Maison Chemical can then review the requirement and provide a supply proposal subject to current availability and agreed specifications. This structured approach gives procurement and technical teams a clearer basis for comparing offers and building a dependable supply plan.
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