3,4,5-Trifluorophenylboronic Acid CAS 143418-49-9: Specifications, COA, SDS, and Supplier Guide

3,4,5-Trifluorophenylboronic acid, CAS 143418-49-9, is a fluorinated aryl boronic acid used primarily as a coupling partner in synthetic chemistry. Its molecular formula is C₆H₄BF₃O₂, and its calculated molecular weight is approximately 175.90 g/mol. At Maison Chemical, I help buyers evaluate this material through the right combination of identity data, batch-specific COA, SDS documentation, packaging, and supply conditions rather than relying on a catalog name alone.

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This guide explains what technical and procurement teams should verify before ordering. I cover typical specification categories, how to review a certificate of analysis, what an SDS can and cannot confirm, and how to compare suppliers for laboratory, process-development, and commercial sourcing. Because product specifications and availability can vary by batch and grade, I recommend confirming the current technical package before purchase.

Key Takeaways for Buyers

• 3,4,5-Trifluorophenylboronic acid is an aryl boronic acid identified by CAS 143418-49-9 and formula C₆H₄BF₃O₂.
• The theoretical molecular weight is approximately 175.90 g/mol, which should be consistent with the formula used in purchasing and reaction calculations.
• A COA is batch-specific evidence of tested quality; an SDS is a safety and handling document, not a replacement for analytical release data.
• Buyers should confirm assay, water, residual solvents, appearance, analytical method, packaging, shelf-life expectations, and shipping conditions.
• Maison Chemical can support quotation review, documentation coordination, packaging discussions, and export-oriented supply inquiries.

Who This Guide Is For

I prepared this guide for procurement specialists, process chemists, medicinal chemistry teams, laboratory managers, and distributors sourcing 3,4,5-Trifluorophenylboronic acid. It is also useful for quality and regulatory reviewers who need to distinguish product identity documents from safety documents. The information is intended to support supplier qualification and technical discussion, not to replace a buyer’s internal risk assessment or laboratory procedures.

The material may be purchased for early-stage synthesis, route scouting, analogue preparation, or process-development work. The appropriate purchasing requirements can change significantly between a small research order and a larger repeat supply program. For that reason, I recommend defining the intended use, required quantity, target purity, delivery country, and documentation requirements before requesting a final quotation.

Basic Chemical Context

3,4,5-Trifluorophenylboronic acid contains a boronic acid functional group attached to a trifluorinated aromatic ring. In many synthetic applications, the boronic acid group is used in palladium-catalyzed carbon–carbon coupling, including Suzuki-type reactions, although the suitable reaction conditions must be established by the user. The three fluorine substituents can influence the electronic character of the aromatic ring, so the compound may be selected when a fluorinated aryl building block is required in a target structure.

Its chemical name and CAS number should be checked against the supplier’s internal specification and analytical records. I do not recommend accepting a CAS match as the only identity confirmation, because a reliable review should also consider analytical data, batch number, molecular formula, and appearance. The exact handling and storage approach should follow the current SDS and the buyer’s own chemical safety system.

Specifications and Material Options

Specification Categories to Review

A commercial specification commonly includes appearance, identification, assay or purity, water content, and relevant impurity controls. Depending on the grade and intended use, the analytical package may also address residual solvents, inorganic residues, or chromatographic impurity profiles. I recommend asking the supplier which methods were used, because a numerical result is more useful when the test method and reporting basis are clear.

The formula-based molecular weight is approximately 175.90 g/mol, and buyers should use the supplier-confirmed value for reaction calculations and inventory systems. A specification limit such as 98% or 99% should never be assumed unless it appears in the current quotation or technical specification. I can help coordinate the applicable product grade and batch documentation, but the final acceptance criteria should come from the buyer’s approved process.

How to Review the COA

A certificate of analysis should be linked to a specific lot or batch number. I advise checking that the product name, CAS number, batch number, manufacturing or retest information, test dates, analytical results, and release status are internally consistent. If the COA lists only a purity value without a method, specification range, or batch reference, I would treat it as incomplete for a formal technical review.

COA Checklist

1. Confirm that the product description matches 3,4,5-Trifluorophenylboronic acid and CAS 143418-49-9.
2. Check the reported assay or purity against the requirement for your synthesis stage.
3. Review identification data and confirm whether the method is suitable for the intended purpose.
4. Look for relevant water, residual solvent, impurity, or loss-on-drying results where applicable.
5. Verify the lot number on the COA matches the lot number on the container label and shipping documents.
6. Ask whether the result is representative of the shipped batch and whether a signed or controlled version is available.

COA values are not universal product constants; they are records of testing for a particular batch. A buyer may therefore request a pre-shipment COA, representative COA, or additional testing depending on the purchase agreement. I recommend resolving this point before dispatch, especially when the material will enter a validated or tightly controlled process.

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How to Use the SDS Correctly

The SDS provides information for hazard communication, safe handling, storage, spill response, exposure control, disposal, and transport review. It should include the product identifier, supplier information, hazard classification where applicable, first-aid measures, firefighting guidance, and other standard safety sections. An SDS does not prove assay, purity, batch identity, or synthetic performance.

Before handling the material, I recommend that the user’s EHS team review the current SDS for the destination country and workplace conditions. Transport classification can depend on the applicable regulations, packaging, quantity, and mode of shipment, so I avoid making an absolute shipping statement without order-specific review. The product should be handled only by trained personnel using the controls and personal protective equipment required by the SDS and site procedures.

Matching the Material to the Application

For medicinal chemistry and discovery synthesis, buyers may prioritize dependable identity, practical pack sizes, and rapid access to documentation. For process development, repeatability, impurity control, and lot-to-lot communication usually become more important. For distribution or larger-scale procurement, packaging configuration, export paperwork, production planning, and continuity of supply may carry greater weight than a single laboratory test result.

Not every supplier’s “high-purity” grade is defined in the same way. I suggest comparing the actual specification, analytical method, and acceptance limits rather than comparing marketing language. If the compound is used in a sensitive coupling step, the chemist may also wish to evaluate water, trace impurities, and handling history as part of a controlled internal study.

Pricing, MOQ, and Lead Time

The price of 3,4,5-Trifluorophenylboronic acid can vary with requested quantity, grade, packaging, testing, destination, and availability. Minimum order quantity and lead time should therefore be quoted against a defined requirement instead of assumed from a general catalog listing. For a new inquiry, I typically recommend specifying the required amount in grams or kilograms, target purity, delivery location, preferred Incoterm if applicable, and documentation package.

Lead time may be shorter for available stock and longer when production, additional testing, or special packaging is required. A clear quotation should identify whether the delivery estimate is based on stock release, manufacturing completion, or document approval. Buyers should also ask about shelf-life or retest information, storage expectations, and the process for handling any quality discrepancy after receipt.

Supplier Evaluation Checklist

Questions I Recommend Asking

• Can the supplier confirm the CAS number, formula, and current product specification?
• Will the COA correspond to the actual shipped lot?
• Is a current SDS available for the destination market?
• Which analytical methods are used for identity and purity testing?
• Can the supplier discuss pack sizes, MOQ, lead time, and repeat-order planning?
• Are custom testing, packaging, or documentation requirements reviewable before order confirmation?
• How are shipping labels, lot traceability, and discrepancy communications managed?

At Maison Chemical, I approach this product as a technical sourcing project rather than a simple name-and-price transaction. We can discuss the intended application, quantity, target specification, COA and SDS needs, packaging preferences, and export destination before preparing a quotation. This helps reduce avoidable delays caused by mismatched grades, incomplete documents, or unsuitable delivery assumptions.

Recommended Next Steps

Start by sending the CAS number, required quantity, target purity, delivery country, and intended use to the supplier. Then request the current specification, representative or batch-specific COA availability, SDS, packaging details, MOQ, and lead time. If the material will be used in a controlled process, add your internal testing or quality requirements before commercial confirmation.

My direct recommendation is to select 3,4,5-Trifluorophenylboronic acid CAS 143418-49-9 only after the identity, specification, COA scope, SDS status, and supply terms are aligned with your project. Maison Chemical can support the review and quotation process for laboratory and commercial sourcing discussions. Contact our team with your exact requirement so we can provide the most relevant product and supply information for evaluation.