4-tert-Buthoxyphenyl boronic acid, CAS 176672-49-4, is an aryl boronic acid used primarily as a synthetic building block in organic and medicinal chemistry. The name is also commonly written as 4-tert-butoxyphenylboronic acid or 4-(tert-butoxy)phenylboronic acid; buyers should confirm the CAS number and structure when comparing documents. It contains a boronic acid group attached to a para-tert-butoxy-substituted phenyl ring and is generally selected for cross-coupling and intermediate synthesis. At Maison Chemical, I support buyers with product identification, batch documentation, packaging discussions, and supply quotations based on their required grade and quantity.
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This compound belongs to the organic boronic acids family. Its boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides, allowing chemists to construct carbon–carbon bonds. The tert-butoxy substituent provides a specific electronic and structural feature that may be useful when designing substituted aromatic intermediates.
A commonly represented molecular formula for 4-tert-butoxyphenylboronic acid is C10H15BO3, with a calculated molecular weight of approximately 194.04 g/mol. These values should be checked against the supplier’s current technical documentation before they are used in a regulated specification, analytical method, or batch calculation. The CAS number remains the most practical identifier for initial purchasing, but structure confirmation is important because similar phenylboronic acid derivatives can have very different performance and handling requirements.
The principal use of this material is as an aryl boronic acid coupling partner. In a Suzuki-type reaction, the aryl boronic acid is combined with an appropriate aryl, heteroaryl, or vinyl halide under a catalyst and base system selected by the chemist. The reaction conditions are project-dependent, so I do not treat one solvent, catalyst loading, temperature, or reaction time as universally applicable.
Medicinal chemistry teams may use this compound to introduce a substituted aromatic ring into a lead structure or intermediate. Its value is often related to the ability to access analogues efficiently during structure–activity relationship studies. Whether it is appropriate for a particular route depends on the target structure, reaction compatibility, purification strategy, and the required impurity profile.
Research organizations and specialty chemical manufacturers may evaluate 4-tert-butoxyphenylboronic acid for the preparation of advanced intermediates, functional aromatic compounds, and materials-related molecules. It may be purchased for small-scale screening, process development, or larger production campaigns. The correct purchasing specification should reflect the intended use rather than rely only on a generic catalog description.
Buyers may encounter this product in different package sizes, grades, and documentation formats. A research-use quantity may be suitable for route screening, while process-development or manufacturing projects may require tighter controls over assay, water, residual solvents, elemental impurities, and trace metals. I recommend defining the application first and then asking the supplier to confirm which parameters can be documented for the relevant batch.
| Specification Area | What Buyers Should Confirm |
|---|---|
| Identity | CAS 176672-49-4, chemical name, molecular structure, and analytical identity data |
| Assay and purity | Reported assay method, acceptance criteria, and whether purity is area percent or another basis |
| Physical form | Typical appearance, batch consistency, and whether special handling is needed during sampling |
| Impurity profile | Water, residual solvents, related substances, and trace metal information where relevant |
| Documentation | Certificate of analysis, safety data sheet, specification sheet, and packing details |
The molecular weight of approximately 194.04 g/mol is useful for stoichiometric planning, but it is not a substitute for a batch-specific certificate of analysis. Buyers should also confirm whether the quoted assay is based on a dry basis, an as-is basis, or a chromatographic method. If the material will enter a validated process, the analytical method and reporting format should be agreed before the purchase order is finalized.
As with other boronic acid intermediates, the material should be handled according to the current safety data sheet and the supplier’s storage recommendation. A buyer should protect the container from avoidable exposure to moisture, heat, contamination, and repeated opening, unless the approved handling procedure states otherwise. The exact stability profile can depend on packaging, storage conditions, container headspace, and the duration of storage.
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For internal planning, some laboratories may request refrigerated storage in the range of 2–8 °C, but this should not be assumed as a universal requirement without confirmation from the product documentation. I recommend that customers ask for the recommended storage temperature, retest or review date if applicable, and any special instructions for shipment. Safe handling also requires appropriate laboratory controls, personal protective equipment, and compliance with local chemical regulations.
Start by checking the CAS number, name variants, molecular formula, and structure. The spelling “Buthoxy” may appear in search queries, while “butoxy” is a more common form in chemical naming; this difference should be resolved in the quotation and technical documents. If your project requires a particular regioisomer, do not approve a substitute based only on a similar product name.
For early reaction screening, a standard research grade may be sufficient if the team can verify performance internally. For process development, higher attention should be given to water, residual solvents, palladium or other trace metals, and related organic impurities. I can review the intended use with the buyer so the requested specification is practical rather than unnecessarily broad.
Required quantity may range from a small laboratory pack to a larger project supply, and the appropriate package depends on consumption rate, storage capacity, and the number of planned batches. MOQ, lead time, export documentation, and shipping conditions should be confirmed in writing because they may vary by quantity, destination, production schedule, and available stock. A buyer should also verify whether the quoted price includes special packaging, documentation, or freight-related services.
A reliable supplier should be able to provide clear product identification and explain which documents are available for the offered batch. At Maison Chemical, I can coordinate requests for a COA, SDS, specification information, packing details, and commercial quotation, subject to the actual batch and order requirements. I do not recommend accepting unsupported claims such as guaranteed reaction performance or universal regulatory suitability without relevant evidence.
Maison Chemical supplies and exports specialty organic intermediates, including 4-tert-butoxyphenyl boronic acid CAS 176672-49-4, for customers evaluating laboratory, development, and manufacturing requirements. I help buyers clarify the required name and CAS number, target quantity, grade expectations, destination, and documentation needs before a quotation is prepared. This process reduces the risk of comparing products that appear similar but have different specifications.
Our support can include product confirmation, batch document review, packaging discussion, shipping coordination, and communication about MOQ or lead time. Availability may depend on current inventory and production planning, so I provide these details after receiving the customer’s requirements rather than presenting an unverified fixed promise. For projects with special impurity limits or customized documentation, early technical communication is especially valuable.
4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4 is a specialized aromatic boronic acid for researchers and manufacturers who need a para-tert-butoxy-substituted aryl building block. It is most relevant when a project requires Suzuki-type coupling or the preparation of a related aromatic intermediate. The best supply decision depends on confirmed identity, application-appropriate purity, batch documentation, packaging, and logistics rather than on the product name alone.
As the next step, prepare your required quantity, target grade, destination, preferred packaging, and documentation list. Send these details to Maison Chemical for product confirmation and a project-specific quotation. I can then help you evaluate whether the available material and supply terms align with your synthesis, development, or production requirements.
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